WE UNDERSTAND! WE KNOW! WE HELP!
The hair plays a very important role in person identification and acts as style item, a reference of beauty The voluminous hair thus means health and youthfulness and hair loss may adversely affect psychosocial status and quality of life.
Few dermatologic problems carry as much emotional overtones as hair loss, both in men and women. Adding to the patient’s worry may be prior frustrating experiences with physicians who tend to trivialize complaints of hair loss or dismiss them completely. We understand that you have reached us because you have a problem. We understand the patient on emotional level, we understand the impact of hair loss on self confidence and we understand the underlying pathophysiology of hair loss. Our doctors-trichologists have extensive experience with hair loss patients, with diagnosis of hair loss and treatment planning for each patient individually.
As with any medical problem, the patient complaining of hair loss requires a comprehensive medical and drug history, physical examination of the hair and scalp, and appropriate laboratory evaluation to identify the cause. The clinician also has a host of diagnostic techniques that enable the classification of the patient’s disorder as a shedding disorder or a decreased density disease as well as the documentation of true or only perceived pathology.
Trichoscopy (hair and scalp dermoscopy) allows identification of hair and scalp diseases based on analysis of trichoscopy structures and patterns. Structures which may be visualized by trichoscopy include hair shafts, hair follicle openings, the perifollicular epidermis and cutaneous microvasculature.
Aram huvis videodermoscope that we use in our practice uses specialized software that allows evaluations of the hair loss stage, calculation of the hair density and number of hairs, measurements of the hair thickness and automatic analysis of the degree of har loss. The keratinization level od the scalp, the scalp sensitivity and pore condition can also be examined, which defines the status of the scalp skin.
With the emergence of stem cells (SCs), many mechanisms that lead to tissue regeneration have been discovered. Hair regeneration has become one of the targets for SC technologies to restore the hair in AGA.
HFSCs are located in the bulge region of the follicle and they interact with mesenchymal SCs (MSCs) located in the dermal papilla (DP). These signal exchanges promote activation of some cellular pathways that are essential for DPC growth, function, and survival, such as the activation of Wnt signaling pathway. Other signals, such as those from endothelial cells (ECs) located at the DP, are also essential for HF maintenance. EC dysfunction that impairs adequate blood supply may limits or inhibits hair growth.
It has been shown that proteins that belong to the transforming growth factor (TGF) superfamily, such as bone morphogenetic proteins (BMPs), also exert signals to maintain the capacity of DPCs to induce HF growing. These BMPs may be released by several cells that compose the follicle, including ECs. Together, dermal blood vessels and DPCs orchestrate a suitable microenvironment for the growth and survival of HFSC
Additionally, BMP6 and fibroblast growth factor 18 (FGF18) from bulge cells exert inhibitory effects on HFSC proliferation. Dihydrotestosterone (DHT) also inhibits HF growth.
SC signalling. Recently, it has been found that SCs release factors that can promote hair growth.Some of these factors, such as epidermal growth factor (EGF), basic fibroblast growth factor, hepatocyte growth factor (HGF) and HGF activator, VEGF, insulin-like growth factor (IGF), TGF-β, and platelet-derived growth factor (PDGF), are able to provide signals that promote hair growth.
It has been shown that Wnt/β-catenin signaling is essential for the growth and maintenance of DPCs Therefore, the increase of Wnt signaling in DPCs apparently is one of the main factors that promote hair growth with Collagen Induced Therapy.
PRP contains more than 20 growth factors like PDGFs (PDGFaa, PDGFbb, PDG-Fab), TGF-β1, TGF-β2, EGF, VEGF, and FGF, that promote the dermal papilla cell proliferation which subsequently means hair regrowth.
TET enhances anagen induction by up-regulating hair follicular cell proliferation and controlling the expressions of FGF-7 and FGF-5, which are involved in anagen induction and cessation, respectively.
Laser therapy promotes hair growth by increasing the blood flow. This increase gives rise to EC proliferation and migration due to upregulation of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase.In addition, the laser energy itself stimulates metabolism in catagen or telogen follicles, resulting in the production of anagen hair.
Scalp threading prolongs the anagen phase of hair growth, which enables linger survival of the hair. Except maintenance of the hair formation it also acts on improvement of the hair thickness. At the same time, prevents the early transition in telogen stage of hair loss.
Some natural ingredients have proven effect on reducing the hair loss and stimulation of the hair growth. The ingredients in DSD de Luxe products like Saw Palmetto extract, alphatradiol, green tea have the capacity to inhibit the action of 5-alpha reductase and block the production of DHT. The apple stem cells , capixyl and other natural ingredients also stimulate the hair growth.
Chemical components like Minoxidil promotes the hair growth through improving the blood circulation and PGE2 production. Dutasterid and Finasterid inhibit 5-alpha reductase and block the conversion of testosteron into dihidrotestosteron.